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The cisplatin molecule is incorporated between two ethacrynate ligand moieties that inhibit the enzymatic activity of GSTP1-1 and liberates the cisplatin molecule as a consequence of binding, which in turn results in the increased localized diffusion of Pt ions and reversion of platinum drug resistance [94]

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Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver